Jennifer Cantley

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

Jennifer Cantley, Toru Yoshimura, João Paulo Camporez et al. · Proceedings of the National Academy of Sciences · 2013 · 154 citations · Full text

Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance

Naoki Kumashiro, Sara A. Beddow, Daniel F. Vatner et al. · Diabetes · 2013 · 154 citations · Full text

Pyruvate Carboxylase Aso, Key Gluconeogenic Enzymes, Metabolic Remodeling +19

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers

Jennifer Cantley, Xiaofen Ye, Emma Rousseau et al. · Nature Communications · 2022 · 115 citations · Full text

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

Naoki Kumashiro, Toru Yoshimura, Jennifer Cantley et al. · Hepatology · 2012 · 87 citations · Full text

PROTACs Targeting BRM (SMARCA2) Afford Selective <i>In Vivo</i> Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models

Michael Berlin, Jennifer Cantley, Mark Bookbinder et al. · Journal of Medicinal Chemistry · 2024 · 23 citations · Full text