Formation of MacroH2A-Containing Senescence-Associated Heterochromatin Foci and Senescence Driven by ASF1a and HIRA

Rugang Zhang, Maxim Poustovoitov, Xiaofen Ye, +11

Developmental Cell

ChromatinChromatin StructureSenescence DrivenChromatin RemodelingNatural Sciences +8

Defective S Phase Chromatin Assembly Causes DNA Damage, Activation of the S Phase Checkpoint, and S Phase Arrest

Xiaofen Ye, Alexa A. Franco, Hidelita Santos, +3

Molecular Cell

ChromatinGenome InstabilityDna DamageChromatin RemodelingS Phase Arrest +8

Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

Elaine E. Storm, Steffen Durinck, Felipe de Sousa e Melo, +15

Nature

Stem-cell FunctionCancer ResearchSignaling PathwayPtprk-rspo3 Colon TumoursMedicine +11

Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells

Xiaofen Ye, Brad J. Zerlanko, Alyssa L. Kennedy, +3

Molecular Cell

ChromatinDevelopmental BiologySignaling PathwayCell RegulationPrimary Human Cells +8

Coupling of DNA Synthesis and Histone Synthesis in S Phase Independent of Cyclin/cdk2 Activity

David M. Nelson, Xiaofen Ye, Caitlin Hall, +6

Molecular and Cellular Biology

Histone ModificationsS Phase CouplingMolecular RegulationEpigenetic ChangeMolecular Biology +19

Definition of pRB- and p53-Dependent and -Independent Steps in HIRA/ASF1a-Mediated Formation of Senescence-Associated Heterochromatin Foci

Xiaofen Ye, Brad J. Zerlanko, Rugang Zhang, +4

Molecular and Cellular Biology

AXL Inhibition Sensitizes Mesenchymal Cancer Cells to Antimitotic Drugs

Catherine Wilson, Xiaofen Ye, Thinh Pham, +9

Cancer Research

Antimitotic DrugsMedicinePharmacologyKinase InhibitorsEmt Setting +10

HIRA, the Human Homologue of Yeast Hir1p and Hir2p, Is a Novel Cyclin-cdk2 Substrate Whose Expression Blocks S-Phase Progression

Caitlin Hall, David M. Nelson, Xiaofen Ye, +5

Molecular and Cellular Biology

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers

Jennifer Cantley, Xiaofen Ye, Emma Rousseau, +26

Nature Communications

Activation Mechanism of Anticoagulant Protein C in Large Blood Vessels Involving the Endothelial Cell Protein C Receptor

Kenji Fukudome, Xiaofen Ye, Naoko Tsuneyoshi, +4

The Journal of Experimental Medicine