Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing

Ji Li, Nicola J. Stagg, Jennifer Johnston, +21

Cancer Cell

Synapse FormationImmunologyImmunoeditingCell DeathImmunologic Mechanism +14

Antibody-drug conjugates targeted to CD79 for the treatment of non-Hodgkin lymphoma

Andrew G. Polson, Shang‐Fan Yu, Kristi Elkins, +18

Blood

Relative Target Affinities of T-Cell–Dependent Bispecific Antibodies Determine Biodistribution in a Solid Tumor Mouse Model

Danielle Mandikian, Nene Takahashi, Ji Li, +12

Molecular Cancer Therapeutics

Avidity-based binding to HER2 results in selective killing of HER2-overexpressing cells by anti-HER2/CD3

Dionysos Slaga, Diego Ellerman, T. Noelle Lombana, +14

Science Translational Medicine

Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody

Karin Staflin, Christina L. Zuch de Zafra, Leah Schutt, +21

JCI Insight

FcRL5 as a Target of Antibody–Drug Conjugates for the Treatment of Multiple Myeloma

Kristi Elkins, Bing Zheng, MaryAnn Go, +10

Molecular Cancer Therapeutics

Hematological MalignancyAntibody–drug ConjugatesMedicineFcrl5 AdcsMalignant Blood Disorder +13

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells

Michael Dillon, Yiyuan Yin, Jianhui Zhou, +13

mAbs

The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma

Veerendra Munugalavadla, Sanjeev Mariathasan, Dionysos Slaga, +10

Oncogene

Hematological MalignancySuperior ActivityMedicineMalignant Blood DisorderClinical Regimens +7

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

Xiaojing Wang, Wesley Blackaby, Vivienne Allen, +31

Journal of Medicinal Chemistry

Pim KinasesPharmacotherapyMetronomic ChemotherapyTumor BiologyPim Kinase Inhibition +16

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability

Xiaojing Wang, Aleksandr Kolesnikov, Suzanne Tay, +17

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryPim KinasesPharmacotherapyLead Series +16