Josefa dela Cruz-Chuh

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy

Peter S. Dragovich, Thomas H. Pillow, Robert A. Blake et al. · Journal of Medicinal Chemistry · 2021 · 159 citations

Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties

Peter S. Dragovich, Thomas H. Pillow, Robert A. Blake et al. · Journal of Medicinal Chemistry · 2021 · 140 citations

High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

Rachana Ohri, Sunil Bhakta, Aimee Fourie-O’Donohue et al. · Bioconjugate Chemistry · 2018 · 109 citations

Molecular Biology, Immunochemistry, Antibody Engineering +16

Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification

Dian Su, Katherine R. Kozak, Jack Sadowsky et al. · Bioconjugate Chemistry · 2018 · 76 citations

Medicinal Chemistry, Drug Targeting, Engineering +15

Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein– and Peptide–Payload Conjugates: Application to THIOMAB Antibody–Drug Conjugates

Jack Sadowsky, Thomas H. Pillow, Jinhua Chen et al. · Bioconjugate Chemistry · 2017 · 59 citations