Josefa dela Cruz-Chuh

Author

WuXi AppTec (China)

Also Known As

Josefa Dela Cruz-Chuh, Josefa dela Cruz-Chuh

Publications

796

Citations

H-Index

Concepts

All Affiliations

WuXi AppTec (China)

About

Josefa dela Cruz-Chuh is an author at WuXi AppTec (China) specializing in medicine, antibody engineering, and drug discovery.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	4	4	234
2	Natural Sciences	3	3	158
3	Biomolecular Engineering	3	3	215
4	Biochemistry	2	2	185
5	Engineering	1	1	76

Josefa dela Cruz-Chuh

Publications

780

Citations

H-Index

Page 1

	Year	Citations
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy Peter S. Dragovich, Thomas H. Pillow, Robert A. Blake, Journal of Medicinal Chemistry	2021	159
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 1: Exploration of Antibody Linker, Payload Loading, and Payload Molecular Properties Peter S. Dragovich, Thomas H. Pillow, Robert A. Blake, Journal of Medicinal Chemistry	2021	140
High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers Rachana Ohri, Sunil Bhakta, Aimee Fourie-O’Donohue, Bioconjugate Chemistry Molecular BiologyImmunochemistryAntibody EngineeringDisulfide-based LinkersVitro Plasma Stabilities	2018	109
Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification Dian Su, Katherine R. Kozak, Jack Sadowsky, Bioconjugate Chemistry Medicinal ChemistryDrug TargetingEngineeringBiochemistryPolymer-drug Conjugate	2018	76
Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein– and Peptide–Payload Conjugates: Application to THIOMAB Antibody–Drug Conjugates Jack Sadowsky, Thomas H. Pillow, Jinhua Chen, Bioconjugate Chemistry	2017	59
Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody–Drug Conjugates Donglu Zhang, Thomas H. Pillow, Yong Ma, ACS Medicinal Chemistry Letters	2016	54
Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers Stephen J. Gregson, Luke A. Masterson, BinQing Wei, Journal of Medicinal Chemistry	2017	37
Immolation of <i>p</i>-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody–Drug Conjugates with Phenol-Containing Payloads Donglu Zhang, Hoa Thi Le, Josefa dela Cruz-Chuh, Bioconjugate Chemistry Drug TargetChemoprevention StrategyPharmacotherapyChemical BiologyPharmaceutical Chemistry	2018	30
Calicheamicin Antibody–Drug Conjugates with Improved Properties Breanna S. Vollmar, Chris Frantz, Melissa M. Schutten, Molecular Cancer Therapeutics	2021	29
Stabilizing a Tubulysin Antibody–Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors Leanna R. Staben, Shang‐Fan Yu, Jinhua Chen, ACS Medicinal Chemistry Letters	2017	26

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