Robert J. Gleave

Discovery and structure–activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor

Muna Abdi, Paul Beswick, Andy Billinton et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 70 citations · Full text

Molecular Pharmacology, Biochemistry, Medicine +10

BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells

Paul Beswick, Nicolas Charrier, Brian Clarke et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 57 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Biochemistry +10

Rhodium-Catalyzed Conjugate Addition−Enantioselective Protonation:  The Synthesis of α,α‘-Dibenzyl Esters

Christopher G. Frost, Stephen D. Penrose, Kim Lambshead et al. · Organic Letters · 2007 · 57 citations

Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB2 agonists for the treatment of inflammatory pain

Robert J. Gleave, Paul Beswick, Andrew J. Brown et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 44 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Anti-inflammatory +14

Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonists

Robert J. Gleave, Daryl S. Walter, Paul Beswick et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 31 citations · Full text

Biological Activity, Bioorganic Chemistry, Biochemistry +7