Jason K. Dutra

Application of the Bicyclo[1.1.1]pentane Motif as a Nonclassical Phenyl Ring Bioisostere in the Design of a Potent and Orally Active γ-Secretase Inhibitor

Antonia F. Stepan, Chakrapani Subramanyam, Ivan Efremov et al. · Journal of Medicinal Chemistry · 2012 · 446 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

SuFEx Activation with Ca(NTf ₂ ) ₂ : A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides

Subham Mahapatra, Cristian P. Woroch, Todd W. Butler et al. · Organic Letters · 2020 · 139 citations · Full text

Pharmacy, Chemistry, Medicinal Chemistry +7

Metabolism-Directed Design of Oxetane-Containing Arylsulfonamide Derivatives as γ-Secretase Inhibitors

Antonia F. Stepan, Kapil Karki, W. Scott McDonald et al. · Journal of Medicinal Chemistry · 2011 · 106 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

Michael A. Brodney, Elizabeth M. Beck, Christopher R. Butler et al. · Journal of Medicinal Chemistry · 2015 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery and Optimization of a Novel Spiropyrrolidine Inhibitor of β-Secretase (BACE1) through Fragment-Based Drug Design

Ivan Efremov, F.F. Vajdos, Kris A. Borzilleri et al. · Journal of Medicinal Chemistry · 2012 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17