Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2

András Váradi, Gina F. Marrone, Travis C. Palmer, +17

Journal of Medicinal Chemistry

Pain MedicineMitragynine/corynantheidine PseudoindoxylsPharmacotherapyExperimental PharmacologyMolecular Pharmacology +18

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

Rajendra Uprety, Tao Che, Saheem A. Zaidi, +21

eLife

Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior

András Váradi, Gina F. Marrone, Shainnel O. Eans, +7

ACS Chemical Neuroscience

Pain MedicineMolecular PainPharmacotherapyExperimental PharmacologyLead Compound +17

Synthesis and Evaluation of Aryl-Naloxamide Opiate Analgesics Targeting Truncated Exon 11-Associated μ Opioid Receptor (MOR-1) Splice Variants

Susruta Majumdar, Joan Subrath, Valerie Le Rouzic, +9

Journal of Medicinal Chemistry

Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction

András Váradi, Travis C. Palmer, Nathan Haselton, +8

ACS Chemical Neuroscience

Molecular PharmacologyMedicinal ChemistryBiochemistryMedicineNatural Sciences +12

Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors

Paweł Nowak, Derek C. Cole, Ann Aulabaugh, +21

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryPharmaceutical ChemistryDrug TargetBiochemistry +11

First generation 5-vinyl-3-pyridinecarbonitrile PKCθ inhibitors

Chuansheng Niu, Diane H. Boschelli, L. Nathan Tumey, +10

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryMedicineOrganic ChemistryPharmacotherapy +4

Three-Component Coupling Approach for the Synthesis of Diverse Heterocycles Utilizing Reactive Nitrilium Trapping

András Váradi, Travis C. Palmer, Paula R. Notis, +7

Organic Letters

Combinatorial ChemistryEngineeringOrganic ChemistryChemistryHeterocycle Chemistry +16

Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCθ inhibitors

Diane H. Boschelli, Daniel Wang, Amar S. Prashad, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicinePkcθ InhibitorsOrganic ChemistryPharmacology +2

C-5 Substituted heteroaryl 3-pyridinecarbonitriles as PKCθ inhibitors: Part I

Joan Subrath, Daniel Wang, Biqi Wu, +6

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryHeterocyclicC-5 SubstitutedMedicine +5