Nino Giorgadze

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.4K citations · Full text

Life Sciences, Cell Biology, Pharmacology +17

Senolytics improve physical function and increase lifespan in old age

Ming Xu, Tamar Pirtskhalava, Joshua N. Farr et al. · Nature Medicine · 2018 · 2.2K citations

Education, Geriatric Medicine, Physiology +14

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

LaTonya J. Hickson, Larissa Prata, Shane A. Bobart et al. · EBioMedicine · 2019 · 1.3K citations · Full text

Veterinary Medicine, Pharmacology, Pharmacotherapy +17

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

Yi Zhu, Tamar Tchkonia, Heike Fuhrmann‐Stroissnigg et al. · Aging Cell · 2015 · 1.1K citations · Full text

Medicine, Molecular Medicine, Pharmacology +16

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Ming Xu, Tamar Tchkonia, Husheng Ding et al. · Proceedings of the National Academy of Sciences · 2015 · 892 citations · Full text

Life Sciences, Cell Biology, Immunology +17