Doyle J. Cassar

Structure-Based Design and Pharmacokinetic Optimization of Covalent Allosteric Inhibitors of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2020 · 85 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of AZD4625, a Covalent Allosteric Inhibitor of the Mutant GTPase KRAS^G12C

Jason G. Kettle, Sharan K. Bagal, Sue Bickerton et al. · Journal of Medicinal Chemistry · 2022 · 63 citations · Full text

Pharmacy, Medicinal Chemistry, Oncology +17

Switchable, Reagent‐Controlled Diastereodivergent Photocatalytic Carbocyclisation of Imine‐Derived α‐Amino Radicals

J. Andrew P. Maitland, Jamie A. Leitch, Ken Yamazaki et al. · Angewandte Chemie International Edition · 2021 · 43 citations · Full text

Natural Sciences, Chemistry, Catalysis +16

Discovery of AZD4747, a Potent and Selective Inhibitor of Mutant GTPase KRAS^G12C with Demonstrable CNS Penetration

Jason G. Kettle, Sharan K. Bagal, Derek Barratt et al. · Journal of Medicinal Chemistry · 2023 · 34 citations · Full text

Medicine, Oncology, Pharmacology +16

Enantioselective Synthesis and Application to the Allylic Imidate Rearrangement of Amine‐Coordinated Palladacycle Catalysts of Cobalt Sandwich Complexes

Doyle J. Cassar, Gennadiy Ilyashenko, Muhammad Ismail et al. · Chemistry - A European Journal · 2013 · 20 citations · Full text

Natural Sciences, Chemistry, Catalysis +16