Exploiting Cancer Cell Vulnerabilities to Develop a Combination Therapy for Ras-Driven Tumors

Thomas De Raedt, Zandra E. Walton, Jessica L. Yecies, +14

Cancer Cell

Tumor BiologyCancer Cell VulnerabilitiesMedicineImmune Checkpoint InhibitorCancer Biology +10

A first-generation pediatric cancer dependency map

Neekesh V. Dharia, Guillaume Kugener, Lillian M. Guenther, +23

Nature Genetics

MedicinePediatricsCancer RegistrationPediatric OncologyOncology +2

mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors

Clare F. Malone, Chloe E. Emerson, Rachel Ingraham, +9

Cancer Discovery

Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers

Sarah Naomi Olsen, Ania Wronski, Zafira Castaño, +13

Cancer Discovery

Defining Key Signaling Nodes and Therapeutic Biomarkers in <i>NF1</i> -Mutant Cancers

Clare F. Malone, Jody Fromm Longo, Ophélia Maertens, +3

Cancer Discovery

Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer

Clare F. Malone, Neekesh V. Dharia, Guillaume Kugener, +17

Cancer Discovery

The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma

Diana Lu, Jana M. Ellegast, Kenneth N. Ross, +16

Nature Cell Biology

Vincristine and bortezomib cause axon outgrowth and behavioral defects in larval zebrafish

Tahsin Khan, Nathan Benaich, Clare F. Malone, +5

Journal of the Peripheral Nervous System

GeneticsVincristine SulfatePharmacotherapyPeripheral NervesExperimental Pharmacology +18

Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors

Clare F. Malone, Minjee Kim, Gabriela Alexe, +12

Cancer Research

The KAT module of the SAGA complex maintains the oncogenic gene expression program in <i>MYCN-</i> amplified neuroblastoma

Clare F. Malone, Nathaniel W. Mabe, Alexandra B. Forman, +9

Science Advances