Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters

Shuofeng Yuan, Zi‐Wei Ye, Ronghui Liang, +27

Science

VaccinationContact TransmissionNew VariantPathogenesisViral Pathogenesis +11

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

Shuofeng Yuan, Xin Yin, Xiangzhi Meng, +42

Nature

Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies

Dongyan Zhou, Jasper Fuk‐Woo Chan, Biao Zhou, +25

Cell Host & Microbe

Systemic Neutralizing AntibodiesImmunologyRespiratory InfectionNasal TurbinatesRobust Sars-cov-2 Infection +3

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

Shuofeng Yuan, Jasper Fuk‐Woo Chan, Kenn Ka-Hang Chik, +13

Pharmacological Research

Drug SafetyFda-approved Drugs BexarotenePreclinical Drug EvaluationMedicineAntiviral Therapy +6

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

Shuofeng Yuan, Chris Chun-Yiu Chan, Kenn Ka-Heng Chik, +13

Viruses

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

Wei Qiao, Hui En Lau, Huizhi Xie, +12

Nature Communications

Viral PathogenesisImmunologyPathologyImmune SystemOsteoporosis +15

Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection

Zi‐Wei Ye, Shuofeng Yuan, Jasper Fuk‐Woo Chan, +13

Emerging Microbes & Infections

Hamster ModelRna ReplicationViral PathogenesisImmunologyAntiviral Drug +14

Targeting papain-like protease for broad-spectrum coronavirus inhibition

Shuofeng Yuan, Xiaopan Gao, Kaiming Tang, +20

Protein & Cell

A molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo

Jasper Fuk‐Woo Chan, Yoo Jin Oh, Shuofeng Yuan, +37

Cell Reports Medicine

Mers-cov InfectionBroad-spectrum Anti-coronavirus LectinDistinct High-mannose GlycansSynthetic VirologyViral Pathogenesis +12

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus

Shuofeng Yuan, Jasper Fuk‐Woo Chan, Zi‐Wei Ye, +13

Viruses