Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility

Jasper Fuk‐Woo Chan, Jinxia Zhang, Shuofeng Yuan, +21

Clinical Infectious Diseases

Surgical Mask Partition Reduces the Risk of Noncontact Transmission in a Golden Syrian Hamster Model for Coronavirus Disease 2019 (COVID-19)

Jasper Fuk‐Woo Chan, Shuofeng Yuan, Jinxia Zhang, +16

Clinical Infectious Diseases

Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters

Shuofeng Yuan, Zi‐Wei Ye, Ronghui Liang, +27

Science

VaccinationContact TransmissionNew VariantPathogenesisViral Pathogenesis +11

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

Shuofeng Yuan, Xin Yin, Xiangzhi Meng, +42

Nature

Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters

Andrew Chak-Yiu Lee, Jinxia Zhang, Jasper Fuk‐Woo Chan, +14

Cell Reports Medicine

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

Shuofeng Yuan, Jasper Fuk‐Woo Chan, Kenn Ka-Hang Chik, +13

Pharmacological Research

Drug SafetyFda-approved Drugs BexarotenePreclinical Drug EvaluationMedicineAntiviral Therapy +6

AMPK-dependent phosphorylation of HDAC8 triggers PGM1 expression to promote lung cancer cell survival under glucose starvation

Yanping Li, Ronghui Liang, Mingming Sun, +9

Cancer Letters

Cell RegulationAmpk-dependent PhosphorylationMedicineCancer Cell BiologyCell Death +9

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

Shuofeng Yuan, Hin Chu, Jingjing Huang, +17

Science Advances

Copper Chaperone for Superoxide Dismutase Promotes Breast Cancer Cell Proliferation and Migration via ROS-Mediated MAPK/ERK Signaling

Yanping Li, Ronghui Liang, Xiaoya Zhang, +5

Frontiers in Pharmacology

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)

Shuofeng Yuan, Chris Chun-Yiu Chan, Kenn Ka-Heng Chik, +13

Viruses