SARS-CoV-2 and COVID-19: The most important research questions

Kit‐San Yuen, Zi‐Wei Ye, Sin‐Yee Fung, +2

Cell & Bioscience

Coronavirus Disease 2019Long CovidVaccine DevelopmentVirus EpidemiologyEmerging Infectious Diseases +12

Severe acute respiratory syndrome Coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3‐dependent ubiquitination of ASC

Kam‐Leung Siu, Kit‐San Yuen, Carlos Castaño-Rodríguez, +8

The FASEB Journal

Acute Lung InjuryLung InflammationImmunologyViral PathogenesisPathology +25

SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

Shuofeng Yuan, Hin Chu, Jasper Fuk‐Woo Chan, +24

Nature Communications

Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters

Shuofeng Yuan, Zi‐Wei Ye, Ronghui Liang, +27

Science

VaccinationContact TransmissionNew VariantPathogenesisViral Pathogenesis +11

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2

Shuofeng Yuan, Xin Yin, Xiangzhi Meng, +42

Nature

Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters

Shuofeng Yuan, Runming Wang, Jasper Fuk‐Woo Chan, +11

Nature Microbiology

MedicineVirus-associated PneumoniaImmunologyAntiviral Drug DevelopmentAntiviral Therapy +9

Inhibition of <scp>AIM</scp> 2 inflammasome activation by a novel transcript isoform of <scp>IFI</scp> 16

Pei‐Hui Wang, Zi‐Wei Ye, Jianjun Deng, +13

EMBO Reports

Transcriptional RegulationSignal TransductionNovel Transcript IsoformSignaling PathwayInflammasome Activation +9

The Arabidopsis Cytosolic Acyl-CoA-Binding Proteins Play Combinatory Roles in Pollen Development

An‐Shan Hsiao, Edward C. Yeung, Zi‐Wei Ye, +1

Plant and Cell Physiology

BiologyPlant Molecular BiologyDevelopmental BiologyPollen GrainsBotany +12

Discovery of the FDA-approved drugs bexarotene, cetilistat, diiodohydroxyquinoline, and abiraterone as potential COVID-19 treatments with a robust two-tier screening system

Shuofeng Yuan, Jasper Fuk‐Woo Chan, Kenn Ka-Hang Chik, +13

Pharmacological Research

Drug SafetyFda-approved Drugs BexarotenePreclinical Drug EvaluationMedicineAntiviral Therapy +6

Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target

Shuofeng Yuan, Hin Chu, Jingjing Huang, +17

Science Advances