M. J. X. Hillebrand

Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception

Noam Zelcer, Koen van de Wetering, M. J. X. Hillebrand et al. · Proceedings of the National Academy of Sciences · 2005 · 214 citations · Full text

Pain Medicine, Molecular Pain, Multidrug Resistance +23

Brain Accumulation of Dasatinib Is Restricted by P-Glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2) and Can Be Enhanced by Elacridar Treatment

Jurjen S. Lagas, Robert A.B. van Waterschoot, Vicky A.C.J. van Tilburg et al. · Clinical Cancer Research · 2009 · 171 citations

Brain accumulation of sunitinib is restricted by P‐glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration

Seng Chuan Tang, Jurjen S. Lagas, Nienke A. G. Lankheet et al. · International Journal of Cancer · 2011 · 155 citations

Neuro-oncology, Bbb Transporters, Chemoprevention Strategy +12

The quantitative analysis of heroin, methadone and their metabolites and the simultaneous detection of cocaine, acetylcodeine and their metabolites in human plasma by high-performance liquid chromatography coupled with tandem mass spectrometry

Elisabeth J. Rook, M. J. X. Hillebrand, Hilde Rosing et al. · Journal of Chromatography B · 2005 · 136 citations

Substance Abuse, Health Sciences, Addiction +13

Pharmacokinetics and Pharmacodynamics of High Doses of Pharmaceutically Prepared Heroin, by Intravenous or by Inhalation Route in Opioid‐Dependent Patients

Elisabeth J. Rook, Jan M. van Ree, Wim van den Brink et al. · Basic & Clinical Pharmacology & Toxicology · 2006 · 122 citations · Full text