Olga Charlat

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

Hong Chen, Olga Charlat, Louis A. Tartaglia et al. · Cell · 1996 · 2.2K citations · Full text

Life Sciences, Endocrinology, Genetics +11

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Shih-Min A. Huang, Yuji Mishina, Shanming Liu et al. · Nature · 2009 · 2.1K citations

Life Sciences, Biochemistry, Cell Biology +10

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

Huai-Xiang Hao, Yang Xie, Yue Zhang et al. · Nature · 2012 · 976 citations

Life Sciences, Biochemistry, Molecular Biology +8

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

Yue Zhang, Shanming Liu, Craig Mickanin et al. · Nature Cell Biology · 2011 · 434 citations

Life Sciences, Biochemistry, Molecular Biology +9

Inactivating mutations of <i>RNF43</i> confer Wnt dependency in pancreatic ductal adenocarcinoma

Xiaomo Jiang, Huai-Xiang Hao, Joseph D. Growney et al. · Proceedings of the National Academy of Sciences · 2013 · 421 citations · Full text

Medicine, Oncology, Pharmacology +17