Concepedia

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

Yue Zhang, Shanming Liu, Craig Mickanin, Feng Yan, Olga Charlat, Gregory A. Michaud, Markus Schirle, Xiaoying Shi, Marc Hild, Andreas Bauer,

Nature Cell Biology · 2011 · 434 citations · 20 references

DOI

Concepts

References

20

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Shih-Min A. Huang, Yuji Mishina, Shanming Liu et al. · Nature · 2009 · 2.1K citations

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Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

Baozhi Chen, Michael Dodge, Wei‐Jen Tang et al. · Nature Chemical Biology · 2009 · 1.4K citations · Full text

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Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling

Jung-Hyun Min, Haifeng Yang, Mircea Ivan et al. · Science · 2002 · 770 citations

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Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

Ann Tsukamoto, Rudolf Grosschedl, Raphael C. Guzman et al. · Cell · 1988 · 748 citations

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The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

Ethan Lee, Adrian Salic, Roland Krüger et al. · PLoS Biology · 2003 · 718 citations · Full text

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