Concepedia

Axin Function

Axin Function is a molecular regulatory mechanism within the Wnt signaling pathway that serves as a scaffold protein to facilitate the phosphorylation and subsequent degradation of β-catenin, thereby maintaining pathway homeostasis in the absence of Wnt ligands.

303

Publications

35.6K

Citations

1.6K

Authors

428

Institutions

Publications per year

2017–2026

62

Parents

Publications

303

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Shih-Min A. Huang, Yuji Mishina, Shanming Liu et al. · Nature · 2009 · 2.1K citations

, , +10

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

Jürgen Behrens, Boris Jerchow, Martin Würtele et al. · Science · 1998 · 1.3K citations

, , +12

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

Satoshi Ikeda · The EMBO Journal · 1998 · 1.3K citations · Full text

, , +10

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

Seiji Satoh, Yataro Daigo, Yoichi Furukawa et al. · Nature Genetics · 2000 · 950 citations

, , +14

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

Li Zeng, François Fagotto, Tong Zhang et al. · Cell · 1997 · 914 citations · Full text

, , +17

1–5 of 303

Authors

1.6K

  1. AK
    Akira Kikuchi

    Hiroshima University, Japan

    15 publications · 2.6K citations

    15

    h-index

  2. SK
    Shosei Kishida

    Hiroshima University, Japan

    11 publications · 2.2K citations

    11

    h-index

  3. JB
    Jürgen Behrens

    Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany

    10 publications · 1.8K citations

    10

    h-index

  4. SL
    Sheng‐Cai Lin

    Xiamen University, China

    13 publications · 1.1K citations

    10

    h-index

  5. FC
    Frank Costantini

    Columbia University, United States

    9 publications · 1.7K citations

    9

    h-index

1–5 of 1.6K

Institutions

428

  1. Hiroshima University

    Hiroshima, Japan

    16 h-index

    72 publications

    20.8K citations

  2. The University of Tokyo

    Tokyo, Japan

    14 h-index

    44 publications

    13.5K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    38 publications

    6.2K citations

  4. Hong Kong University of Science and Technology

    Hong Kong, Hong Kong

    12 h-index

    68 publications

    6.1K citations

  5. University of Washington

    Seattle, United States

    11 h-index

    38 publications

    5.7K citations

  6. Xiamen University

    Xiamen, China

    11 h-index

    67 publications

    5.4K citations

  7. University of Hong Kong

    Pok Fu Lam, Hong Kong

    10 h-index

    44 publications

    4.6K citations

  8. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    9 h-index

    28 publications

    3.5K citations

1–8 of 428

Venues

  1. Journal of Biological Chemistry

    JBC · 33 publications · 3.5K citations

    32

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 16 publications · 2.3K citations

    16

    h-index

  3. PLoS ONE

    13 publications · 757 citations

    13

    h-index

  4. Molecular and Cellular Biology

    MCB · 12 publications · 1.6K citations

    12

    h-index

  5. Genes & Development

    11 publications · 2.8K citations

    11

    h-index

1–5