Kai Schlepckow

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

Marc Suárez‐Calvet, Estrella Morenas‐Rodríguez, Gernot Kleinberger et al. · Molecular Neurodegeneration · 2019 · 380 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

Kai Schlepckow, Kathryn M. Monroe, Gernot Kleinberger et al. · EMBO Molecular Medicine · 2020 · 357 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

Kai Schlepckow, Gernot Kleinberger, Akio Fukumori et al. · EMBO Molecular Medicine · 2017 · 294 citations · Full text

Life Sciences, Biochemistry, Neurology +14

A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models

Bettina van Lengerich, Lihong Zhan, Dan Xia et al. · Nature Neuroscience · 2023 · 222 citations · Full text

Medicine, Neurobiology, Neuroscience +17

Three-state mechanism couples ligand and temperature sensing in riboswitches

Anke Reining, Senada Nožinović, Kai Schlepckow et al. · Nature · 2013 · 216 citations

Natural Sciences, Biochemistry, Chemistry +10