Michael Grzelak

Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks

Alexandre Paix, Andrew W. Folkmann, Daniel Goldman et al. · Proceedings of the National Academy of Sciences · 2017 · 236 citations · Full text

SCH 57790, a selective muscarinic M2 receptor antagonist, releases acetylcholine and produces cognitive enhancement in laboratory animals

Galen Carey, William Billard, Herbert Binch et al. · European Journal of Pharmacology · 2001 · 76 citations

Molecular Pharmacology, Laboratory Animals, Medicine +8

Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation

Mihirbaran Mandal, Zhaoning Zhu, Jared N. Cumming et al. · Journal of Medicinal Chemistry · 2012 · 56 citations · Full text

Combinatorial Chemistry, Bicyclic Iminopyrimidinones, Pseudoaxial Conformation +21

Structure-Based Design of an Iminoheterocyclic β-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aβ in Nonhuman Primates

Mihirbaran Mandal, Yusheng Wu, Jeffrey Misiaszek et al. · Journal of Medicinal Chemistry · 2016 · 41 citations · Full text

A Skin Rejection Grading System for Vascularized Composite Allotransplantation in a Preclinical Large Animal Model

Joanna W. Etra, Michael Grzelak, Samuel A. J. Fidder et al. · Transplantation · 2019 · 31 citations · Full text