Dual proteome-scale networks reveal cell-specific remodeling of the human interactome

Edward L. Huttlin, Raphael J. Bruckner, José Navarrete-Perea, +25

Cell

Signal TransductionDual Proteome-scale NetworksCell DivisionInteractomicsMedicine +10

Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes

Nazar Mashtalir, Brittany C. Michel, Jie Luo, +11

Cell

ChromatinModular OrganizationChromatin StructureChromatin RemodelingNatural Sciences +7

Extracting Biological Insights from the Project Achilles Genome-Scale CRISPR Screens in Cancer Cell Lines

Joshua M. Dempster, Jordan Rossen, Mariya Kazachkova, +4

Project AchillesEngineeringGenetic DependenciesGeneticsMolecular Biology +19

A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation

Brittany C. Michel, Seth H. Cassel, Nazar Mashtalir, +15

Nature Cell Biology

Non-canonical Swi/snf ComplexOncogenic AgentMedicineSynthetic Lethal TargetCancer Genomics +7

Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

Hanghang Zhang, Somnath Pandey, Meghan Travers, +30

Cell

Cancer GenomicsTumor SuppressorMedicineCell BiologyTumor Microenvironment +1

Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

Joshua Pan, Robin M. Meyers, Brittany C. Michel, +10

Cell Systems

Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis

Gabriel J. Sandoval, John L. Pulice, Hubert Pakula, +16

Molecular Cell

ChromatinTranscriptional RegulationSignal TransductionChromatin StructureChromatin Remodeling +8

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, José Navarrete-Perea, +23

Molecular BiologyCytoskeletonProteomic TechnologyCell InteractionBiological Network +15

The ATPase module of mammalian SWI/SNF family complexes mediates subcomplex identity and catalytic activity–independent genomic targeting

Joshua Pan, Zachary M. McKenzie, Nazar Mashtalir, +5

Nature Genetics

Atpase ModuleCatalytic Activity–independent GenomicSignal TransductionProtein FunctionNatural Sciences +7

Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers

Rita Sulahian, Jason J. Kwon, Katherine H. Walsh, +28

Cell Reports

Synthetic Lethal InteractionShoc2 DepletionCancer BiologyTumor BiologySignaling Pathway +15