Jian Yuan Goh

IFI16-dependent STING signaling is a crucial regulator of anti-HER2 immune response in HER2+ breast cancer

L.S. Ong, Wee Chyan Lee, Shijun Ma et al. · Proceedings of the National Academy of Sciences · 2022 · 565 citations · Full text

<i>VHL</i> Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma

Xiaosai Yao, Jing Tan, Kevin Lim et al. · Cancer Discovery · 2017 · 179 citations · Full text

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel

Zhen Ning Wee, Siti Maryam J. M. Yatim, Vera Kohlbauer et al. · Nature Communications · 2015 · 169 citations · Full text

Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence

Jian Yuan Goh, Min Feng, Wenyu Wang et al. · Nature Medicine · 2017 · 152 citations

Chromatin, Systems Biology, Breast Cancer Recurrence +14

Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy

Shijun Ma, Yue Zhao, Wee Chyan Lee et al. · Nature Communications · 2022 · 152 citations · Full text

Breast Oncology, Immunology, Immune Regulation +22