Qing Han

Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice.

Xiao Sun, Min Xu, Xiaojun Tan et al. · PubMed · 1999 · 125 citations

Medicine, Oncology, Pharmacology +16

Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice.

Demetrius M. Kokkinakis, Richard M. Hoffman, E. P. Frenkel et al. · PubMed · 2001 · 123 citations

Medicine, Oncology, Pharmacology +8

Recombinant methioninase infusion reduces the biochemical endpoint of serum methionine with minimal toxicity in high-stage cancer patients.

Yuying Tan, Jorge Zavala, Qing Han et al. · PubMed · 1998 · 80 citations

Medicine, Oncology, Pharmacokinetics +13

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Frank Ruebsam, Douglas E. Murphy, Chinh Van Tran et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 43 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7′-substitution of benzothiadiazine

Yuefen Zhou, Stephen E. Webber, Douglas E. Murphy et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 41 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +12