Frank Ruebsam

Novel Autotaxin Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis: A Clinical Candidate Discovered Using DNA-Encoded Chemistry

John W. Cuozzo, Matthew Clark, Anthony D. Keefe et al. · Journal of Medicinal Chemistry · 2020 · 110 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Frank Ruebsam, Douglas E. Murphy, Chinh Van Tran et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 43 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7′-substitution of benzothiadiazine

Yuefen Zhou, Stephen E. Webber, Douglas E. Murphy et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 41 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +12

Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Frank Ruebsam, Stephen E. Webber, Martin T. Tran et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 37 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +12

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments

Lian‐Sheng Li, Yuefen Zhou, Douglas E. Murphy et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 35 citations

Pharmacy, Medicinal Chemistry, Pharmacokinetics +16