Douglas E. Murphy

Structure-based Design of Pyridone–Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition

Siegfried Reich, Paul A. Sprengeler, Gary G. Chiang et al. · Journal of Medicinal Chemistry · 2018 · 177 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Synthesis and SAR of 3,5-diamino-piperidine derivatives: Novel antibacterial translation inhibitors as aminoglycoside mimetics

Yuefen Zhou, V. Gregor, Benjamin K. Ayida et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 128 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Optimization of Alkylidene Hydrazide Based Human Glucagon Receptor Antagonists. Discovery of the Highly Potent and Orally Available 3-Cyano-4-hydroxybenzoic Acid [1-(2,3,5,6-Tetramethylbenzyl)-1<i>H</i>-indol-4-ylmethylene]hydrazide

Peter Madsen, Anthony Ling, Michael Plewe et al. · Journal of Medicinal Chemistry · 2002 · 87 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-Guided Discovery of Novel Aminoglycoside Mimetics as Antibacterial Translation Inhibitors

Yuefen Zhou, V. Gregor, Zhongxiang Sun et al. · Antimicrobial Agents and Chemotherapy · 2005 · 59 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Frank Ruebsam, Douglas E. Murphy, Chinh Van Tran et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 43 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15