J. Jasti

Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH

J. Jasti, Hiroyasu Furukawa, Eric B. Gonzales et al. · Nature · 2007 · 1.1K citations

Natural Sciences, Biochemistry, Biophysics +15

Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7 <i>H</i> -pyrrolo[2,3- <i>d</i> ]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor

Jaclyn L. Henderson, Bethany L. Kormos, Matthew M. Hayward et al. · Journal of Medicinal Chemistry · 2014 · 182 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

First Structural Evidence of a Specific Inhibition of Phospholipase A2 by α-Tocopherol (Vitamin E) and its Implications in Inflammation: Crystal Structure of the Complex Formed Between Phospholipase A2 and α-Tocopherol at 1.8Å Resolution

Vikas Chandra, J. Jasti, Punit Kaur et al. · Journal of Molecular Biology · 2002 · 107 citations

Life Sciences, Biochemistry, Pharmacology +13

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose

Kentaro Futatsugi, Aaron Smith, Meihua Tu et al. · Journal of Medicinal Chemistry · 2020 · 75 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structural Basis of Phospholipase A₂ Inhibition for the Synthesis of Prostaglandins by the Plant Alkaloid Aristolochic Acid from a 1.7 Å Crystal Structure^,

Vikas Chandra, J. Jasti, Punit Kaur et al. · Biochemistry · 2002 · 69 citations

Life Sciences, Biochemistry, Molecular Biology +15