Deepali Gotur

Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

Justin A. Caravella, Jian Lin, R. Bruce Diebold et al. · Journal of Medicinal Chemistry · 2020 · 144 citations · Full text

Pharmacy, Oncology, Pharmacology +15

Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer

Antoine Simoneau, Justin L. Engel, Madhavi Bandi et al. · Molecular Cancer Therapeutics · 2022 · 73 citations · Full text

Life Sciences, Genetics, Oncology +15

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with <i>MTAP</i>-Deleted Cancers

Kevin M. Cottrell, Kimberly J. Briggs, Douglas A. Whittington et al. · Journal of Medicinal Chemistry · 2024 · 67 citations · Full text

Medicine, Oncology, Pharmacology +13

Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors

Jian Lin, Wei Lu, Justin A. Caravella et al. · Journal of Medicinal Chemistry · 2019 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Lamin B Receptor Regulates the Growth and Maturation of Myeloid Progenitors via its Sterol Reductase Domain: Implications for Cholesterol Biosynthesis in Regulating Myelopoiesis

Gayathri Subramanian, Pulkit Chaudhury, Krishnakumar Malu et al. · The Journal of Immunology · 2011 · 38 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15