Roger H. Pak

Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90

Jens Sydor, Emmanuel Normant, Christine Pien et al. · Proceedings of the National Academy of Sciences · 2006 · 227 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Design, Synthesis, and Biological Evaluation of Hydroquinone Derivatives of 17-Amino-17-demethoxygeldanamycin as Potent, Water-Soluble Inhibitors of Hsp90

Jie Ge, Emmanuel Normant, James R. Porter et al. · Journal of Medicinal Chemistry · 2006 · 189 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I–induced leukemia and suppresses leukemic stem cells

Cong Peng, Julia Brain, Yiguo Hu et al. · Blood · 2007 · 145 citations · Full text

Medicine, Oncology, Pharmacology +14

Preparation and properties of nido-carborane-specific monoclonal antibodies for potential use in boron neutron capture therapy for cancer.

Roger H. Pak, F. James Primus, K J Rickard-Dickson et al. · Proceedings of the National Academy of Sciences · 1995 · 45 citations · Full text

Pharmacy, Biochemistry, Oncology +16

Synthesis and Structural Characterization of [Me3NH][nido-9,11-I2-7,8-C2B9H10] and [Me3NH][nido-9-I-7,8-C2B9H11]

Roger H. Pak, Robert R. Kane, Carolyn B. Knobler et al. · Inorganic Chemistry · 1994 · 35 citations

Natural Sciences, Chemistry, Inorganic Chemistry +5