Yuka E. Lewis

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease

Nicholas P. Marotta, Yu Lin, Yuka E. Lewis et al. · Nature Chemistry · 2015 · 300 citations · Full text

Neurodegenerative Diseases, O-glcnac Modification, Biochemistry +5

O-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding

Yuka E. Lewis, Ana Galesic, Paul M. Levine et al. · ACS Chemical Biology · 2017 · 103 citations · Full text

Proteinlipid Interaction, Protein Secretion, Protein Assembly +26

O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein

Paul M. Levine, Cesar A. De Leon, Ana Galesic et al. · Bioorganic & Medicinal Chemistry · 2017 · 44 citations · Full text

Neurodegenerative Diseases, Molecular Neuroscience, O-glcnac Modification +8

Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α-Synuclein Aggregation and Toxicity

Yuka E. Lewis, Tharindumala Abeywardana, Yu Lin et al. · ACS Chemical Biology · 2016 · 35 citations · Full text