Cesar A. De Leon

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson’s disease

Paul M. Levine, Ana Galesic, Aaron T. Balana et al. · Proceedings of the National Academy of Sciences · 2019 · 228 citations · Full text

O-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding

Yuka E. Lewis, Ana Galesic, Paul M. Levine et al. · ACS Chemical Biology · 2017 · 103 citations · Full text

Proteinlipid Interaction, Protein Secretion, Protein Assembly +26

The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels

Cesar A. De Leon, Paul M. Levine, Timothy W. Craven et al. · Biochemistry · 2017 · 74 citations · Full text

Glycobiology, Molecular Biology, Peptide Science +20

Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies

Kanak Raina, Chris D. Forbes, Rebecca Stronk et al. · Cell chemical biology · 2024 · 50 citations · Full text

Tumor Biology, Drug Targeting, Medicine +13

O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein

Paul M. Levine, Cesar A. De Leon, Ana Galesic et al. · Bioorganic & Medicinal Chemistry · 2017 · 44 citations · Full text

Neurodegenerative Diseases, Molecular Neuroscience, O-glcnac Modification +8