Nicholas P. Marotta

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease

Nicholas P. Marotta, Yu Lin, Yuka E. Lewis et al. · Nature Chemistry · 2015 · 308 citations · Full text

Life Sciences, Biochemistry, Neuroscience +12

Semisynthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation

Franziska Meier, Tharindumala Abeywardana, Abhinav Dhall et al. · Journal of the American Chemical Society · 2012 · 112 citations

Life Sciences, Biochemistry, Molecular Biology +15

Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro

Nicholas P. Marotta, Jahan Ara, Norihito Uemura et al. · Acta Neuropathologica Communications · 2021 · 82 citations · Full text

Life Sciences, Neurology, Neuroscience +17

The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8

Kelly N. Chuh, Anna R. Batt, Balyn W. Zaro et al. · Journal of the American Chemical Society · 2017 · 62 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

α-Synuclein aggregates amplified from patient-derived Lewy bodies recapitulate Lewy body diseases in mice

Norihito Uemura, Nicholas P. Marotta, Jahan Ara et al. · Nature Communications · 2023 · 61 citations · Full text

Life Sciences, Neurology, Neuroscience +16