Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

Norihito Uemura, Hisashi Yagi, Maiko Uemura, +3

Molecular Neurodegeneration

α-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson’s disease model

Tomoyuki Taguchi, Masashi Ikuno, Mari Hondo, +18

Brain

NeurogenomicsSporadic ParkinsonGeneticsMolecular BiologyGene Characterization +27

Efficient Targeted Mutagenesis in Medaka Using Custom-Designed Transcription Activator-Like Effector Nucleases

Satoshi Ansai, Tetsushi Sakuma, Takashi Yamamoto, +4

Genetics

Amino AcidsGeneticsMolecular BiologyMolecular GeneticsTranscriptional Regulation +18

Design, evaluation, and screening methods for efficient targeted mutagenesis with transcription activator‐like effector nucleases in medaka

Satoshi Ansai, Keiji Inohaya, Yasutoshi Yoshiura, +4

Development Growth & Differentiation

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

Seiji Kaji, Takakuni Maki, Hisanori Kinoshita, +14

Stem Cell Reports

Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (α-Syn) Pathology in Synthetic α-Syn Fibril-Induced Mouse Models of Synucleinopathy

Norihito Uemura, Maiko Uemura, Angela Lo, +6

Journal of Neuropathology & Experimental Neurology

Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro

Nicholas P. Marotta, Jahan Ara, Norihito Uemura, +6

Acta Neuropathologica Communications

ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease

Masaki Nakano, Hiromi Imamura, Norio Sasaoka, +6

EBioMedicine

Viable Neuronopathic Gaucher Disease Model in Medaka (Oryzias latipes) Displays Axonal Accumulation of Alpha-Synuclein

Norihito Uemura, Masato Koike, Satoshi Ansai, +10

PLoS Genetics

Glial BiologySporadic ParkinsonNeurochemical BiomarkersSynaptic SignalingSocial Sciences +20

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint‐like inclusion body formation, and selective degeneration of dopaminergic neurons

Hideaki Matsui, Fumiaki Sato, Shigeto Sato, +13

FEBS Letters