Luc de Waal

Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing

Marcin Imieliński, Alice H. Berger, Peter S. Hammerman et al. · Cell · 2012 · 1.8K citations · Full text

Medicine, Molecular Biology, Oncology +14

A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events

Angela N. Brooks, Peter S. Choi, Luc de Waal et al. · PLoS ONE · 2014 · 185 citations · Full text

Life Sciences, Genetics, Oncology +14

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics

Luc de Waal, Timothy A. Lewis, Matthew G. Rees et al. · Nature Chemical Biology · 2015 · 97 citations

Medicine, Oncology, Pharmacology +12

Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase

Colin W. Garvie, Xiaoyun Wu, Malvina Papanastasiou et al. · Nature Communications · 2021 · 90 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing

Timothy A. Lewis, Luc de Waal, Xiaoyun Wu et al. · ACS Medicinal Chemistry Letters · 2019 · 28 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14