Nicole L. Valvano

A highly selective protocol for the deprotection of BOC-protected amides and carbamates

Jeffrey A. Stafford, Marcus F. Brackeen, Donald S. Karanewsky et al. · Tetrahedron Letters · 1993 · 89 citations

Pharmacy, Medicinal Chemistry, Synthetic Medicinal Chemistry +6

Synthesis of 2-aminobenzophenones via rapid halogen-lithium exchange in the presence of a 2-amino-N-methoxy-N-methylbenzamide

Stephen V. Frye, M.C. Johnson, Nicole L. Valvano · The Journal of Organic Chemistry · 1991 · 39 citations

Natural Sciences, Chemistry, Biocatalysis +5

A Unified Strategy for the Synthesis of Highly Substituted Dihydrobenzofurans and Dihydrobenzopyrans

Jeffrey A. Stafford, Nicole L. Valvano · The Journal of Organic Chemistry · 1994 · 29 citations

Natural Sciences, Chemistry, Drug Discovery +5

Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of methyl (R*,R*)-(.+-.)-3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase.

Jeffrey A. Stafford, James M. Veal, Paul L. Feldman et al. · Journal of Medicinal Chemistry · 1995 · 19 citations · Full text

Medicine, Chemistry, Pharmacology +9

Structure-activity relationships involving the catechol subunit of rolipram

Jeffrey A. Stafford, Paul L. Feldman, Brian E. Marron et al. · Bioorganic & Medicinal Chemistry Letters · 1994 · 15 citations

Life Sciences, Biochemistry, Pharmacology +11