Donald S. Karanewsky

Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-<i>N</i>2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-<i>N</i>4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials

Thomas H. Marsilje, Wei Pei, Bei Chen et al. · Journal of Medicinal Chemistry · 2013 · 405 citations · Full text

Chemoprevention Strategy, Pharmacotherapy, Structure–activity Relationships +21

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

Robert C. Armstrong, Teresa Aja, Jialing Xiang et al. · Journal of Biological Chemistry · 1996 · 319 citations · Full text

Activation of the CED3/ICE-Related Protease CPP32 in Cerebellar Granule Neurons Undergoing Apoptosis But Not Necrosis

Robert C. Armstrong, Teresa Aja, Kim Hoang et al. · Journal of Neuroscience · 1997 · 282 citations · Full text

Ced3/ice-related Protease Cpp32, Apoptosis, Granule Neurons +17

Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone

Peer R. E. Mittl, Stefania Di Marco, Joseph Krebs et al. · Journal of Biological Chemistry · 1997 · 247 citations · Full text

Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2

Tao Jiang, Kelli Kuhen, Karen C. Wolff et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 197 citations

Medicinal Chemistry, Biochemistry, Biological Evaluations +11