Eddine Saiah

Approaches to discover non-ATP site kinase inhibitors

Lori K. Gavrin, Eddine Saiah · MedChemComm · 2012 · 170 citations

Medicinal Chemistry, Drug Target, Biochemistry +12

Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( <i>S</i> )-2,2-Difluorocyclopropyl)((1 <i>R</i> ,5 <i>S</i> )-3-(2-((1-methyl-1 <i>H</i> -pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)

Andrew Fensome, Catherine M. Ambler, Eric P. Arnold et al. · Journal of Medicinal Chemistry · 2018 · 165 citations · Full text

Discovery of Clinical Candidate 1-{[(2 <i>S</i> ,3 <i>S</i> ,4 <i>S</i> )-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

Katherine L. Lee, Catherine M. Ambler, David R. Anderson et al. · Journal of Medicinal Chemistry · 2017 · 138 citations · Full text

A small molecule inhibitor of Rheb selectively targets mTORC1 signaling

Sarah J. Mahoney, Sridhar Narayan, Lisa Molz et al. · Nature Communications · 2018 · 95 citations · Full text

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

Luisa Quinti, Malcolm Casale, S. Moniot et al. · Cell chemical biology · 2016 · 85 citations · Full text

Disease Models, Neurodegenerative Diseases, Nrf2-targeting Thiazole-containing Compound +7