Lactic acid promotes PD-1 expression in regulatory T cells in highly glycolytic tumor microenvironments

Shogo Kumagai, Shohei Koyama, Kota Itahashi, +43

Cancer Cell

Cancer ImmunosurveillancePd-1 ExpressionMedicineT-regulatory CellImmunology +9

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

Tetsuya Kimura, Shigeyuki Nada, Noriko Takegahara, +17

Nature Communications

Intestinal Epithelial Cell-Derived Semaphorin 7A Negatively Regulates Development of Colitis via αvβ1 Integrin

Sujin Kang, Tatsusada Okuno, Noriko Takegahara, +10

The Journal of Immunology

Distinct contributions of TNF and LT cytokines to the development of dendritic cells in vitro and their recruitment in vivo

Koichiro Abe, Felix Yarovinsky, Takaya Murakami, +8

Blood

Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis

Masayuki Nishide, Satoshi Nojima, Daisuke Ito, +18

Annals of the Rheumatic Diseases

Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20

Kipp Weiskopf, Katie L. Anderson, Daisuke Ito, +15

Cancer Immunology Research

ImmunologyImmune RegulationPathologyImmunoeditingImmunologic Mechanism +23

Mice with a Targeted Mutation in Lymphotoxin-α Exhibit Enhanced Tumor Growth and Metastasis: Impaired NK Cell Development and Recruitment

Daisuke Ito, Timothy Back, Alexander N. Shakhov, +2

The Journal of Immunology

Lymphocyte DevelopmentAdaptive Immune SystemImmunologyImmune RegulationNk Cells +17

Isolation and characterization of canine natural killer cells

Helen Michael, Daisuke Ito, Valarie McCullar, +3

Veterinary Immunology and Immunopathology

Laboratory ImmunologyVeterinary PathologyImmunologyVeterinary ScienceMedicine +2

Evolutionarily conserved resistance to phagocytosis observed in melanoma cells is insensitive to upregulation of pro-phagocytic signals and to CD47 blockade

Katie L. Anderson, Kristin M. Snyder, Daisuke Ito, +9

Melanoma Research

ImmunologyImmunologic MechanismCd47 BlockadeImmunotherapyMelanoma Cells +17

Gene expression profiles of oral leukoplakia and carcinoma: Genome-wide comparison analysis using oligonucleotide microarray technology

Takeshi Odani, Daisuke Ito, Ming-Heng Li, +4

International Journal of Oncology

PathologyGenome-wide Comparison AnalysisOligonucleotide Microarray TechnologyGene Expression ProfilingOral Potentially Malignant Disorders +14