Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus

Yasuhiro Kato, JeongHoon Park, Hyota Takamatsu, +12

Annals of the Rheumatic Diseases

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

Tetsuya Kimura, Shigeyuki Nada, Noriko Takegahara, +17

Nature Communications

Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization

Sujin Kang, Yoshimitsu Nakanishi, Yoshiyuki Kioi, +14

Nature Immunology

InflammationAnti-inflammatorySignal TransductionInflammatory DiseaseReverse Signaling Controls +11

Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications

Yūji Yoshida, Atsushi Ogata, Sujin Kang, +16

Arthritis & Rheumatology

Development and validation of a deep-learning model for scoring of radiographic finger joint destruction in rheumatoid arthritis

Tôru Hirano, Masayuki Nishide, Naoki Nonaka, +4

Rheumatology Advances in Practice

Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis

Masayuki Nishide, Satoshi Nojima, Daisuke Ito, +18

Annals of the Rheumatic Diseases

Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity

Takeshi Tsuda, Yohei Maeda, Masayuki Nishide, +15

International Immunology

AsthmaInflammatory Lung DiseaseLung InflammationImmunologyEosinophilic Disorder +14

mTOR Complex Signaling through the SEMA4A–Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells

Daisuke Ito, Satoshi Nojima, Masayuki Nishide, +17

The Journal of Immunology

Lymphocyte DevelopmentMtorc1 ActivityImmune RegulationImmunologyImmunologic Mechanism +20

Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells

Yuhei Kinehara, Izumi Nagatomo, Shohei Koyama, +32

JCI Insight

Egfr-tki ResistanceCancer BiologyTumor BiologyMtor ActivationCancer Cell Biology +15

Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome

Hachiro Konaka, Yasuhiro Kato, Tôru Hirano, +23

The EMBO Journal