Characterization of human type I and type II IMP dehydrogenases.

Stephen F. Carr, Eva Papp, J. Wu, +1

Journal of Biological Chemistry

Type Ii EnzymeAldo-keto ReductaseGeneticsMolecular BiologyEscherichia Coli +14

Molecular Mechanism of the Syk Activation Switch

Emily K. Tsang, Anthony M. Giannetti, David E. Shaw, +7

Journal of Biological Chemistry

Design and Synthesis of 4-Azaindoles as Inhibitors of p38 MAP Kinase

Alejandra Trejo, Humberto Arzeno, Michelle F. Browner, +24

Journal of Medicinal Chemistry

Combinatorial ChemistryBioorganic ChemistryP38 Map KinaseP38 InhibitorsOrganic Chemistry +15

Pamapimod, a Novel p38 Mitogen-Activated Protein Kinase Inhibitor: Preclinical Analysis of Efficacy and Selectivity

Ronald J. Hill, Karim Dabbagh, Deborah Phippard, +16

Journal of Pharmacology and Experimental Therapeutics

Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2<i>H</i>-pyran-4-ylamino)pyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase

David Goldstein, Michael Soth, Tobias Gabriel, +35

Journal of Medicinal Chemistry

PharmacotherapyNew SeriesSystem PharmacologyPharmaceutical ChemistryPre-clinical Pharmacology +19

Discovery of <i>S</i>-[5-Amino-1-(4-fluorophenyl)-1<i>H</i>-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an Orally Bioavailable and Highly Selective Inhibitor of p38 Map Kinase

David Goldstein, Tom Alfredson, J. A. Bertrand, +29

Journal of Medicinal Chemistry

Structure−Activity Relationships for Inhibition of Inosine Monophosphate Dehydrogenase by Nuclear Variants of Mycophenolic Acid

Peter H. Nelson, Stephen F. Carr, Bruce H. Devens, +16

Journal of Medicinal Chemistry

3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: Design and development to a highly selective lead

Michael Soth, Sarah C. Abbot, Allassan Abubakari, +24

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryDrug TargetBiochemistryMedicine +9

Steady State Kinetics of Spleen Tyrosine Kinase Investigated by a Real Time Fluorescence Assay

Eva Papp, Joyce Ka Yu Tse, Hoangdung Ho, +6

Biochemistry

Steady State KineticsCytoskeletonCellular PhysiologyFluorescence AssayReceptor Tyrosine Kinase +17

Rationally Designed Inhibitors of Inosine Monophosphate Dehydrogenase

Han‐Zhong Zhang, K. Sudhindra Rao, Stephen F. Carr, +4

Journal of Medicinal Chemistry

Medicinal ChemistryBiosynthesisBioorganic ChemistryCellular EnzymologyBiochemistry +11