Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

Justin D. Crane, Rengasamy Palanivel, Emilio P. Mottillo, +15

Nature Medicine

ObesityMetabolic SyndromeEnergy HomeostasisBody CompositionBiochemistry +10

AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

Adam L. Bujak, Justin D. Crane, James Lally, +8

Cell Metabolism

Cell AutophagyMitophagyMuscle FunctionSkeletal MusclePhysiology +6

Exercise‐stimulated interleukin‐15 is controlled by<scp>AMPK</scp>and regulates skin metabolism and aging

Justin D. Crane, Lauren MacNeil, James Lally, +7

Aging Cell

AgingImmunologyBiogerontologyDermatologyInflammation +21

Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

Rebecca J. Ford, Morgan D. Fullerton, Stephen L. Pinkosky, +11

Biochemical Journal

Inhibit LipogenesisFatty Liver DiseaseInsulin SignalingMetabolic SyndromeMolecular Pharmacology +22

Lifelong aerobic exercise protects against inflammaging and cancer

Mats I. Nilsson, Jacqueline M. Bourgeois, Joshua P. Nederveen, +15

PLoS ONE

Physical ActivityAgingAerobic ExerciseImmunologyExercise Medicine +19

AMPK deficiency in cardiac muscle results in dilated cardiomyopathy in the absence of changes in energy metabolism

Miranda M. Sung, Beshay N. Zordoky, Adam L. Bujak, +9

Cardiovascular Research

The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice

Katarina Marcinko, Adam L. Bujak, James Lally, +9

Molecular Metabolism

Nutritional co-therapy with 1,3-butanediol and multi-ingredient antioxidants enhances autophagic clearance in Pompe disease

Mats I. Nilsson, Michael Crozier, Alessia Di Carlo, +10

Molecular Genetics and Metabolism

NutritionPompe DiseaseCell AutophagyAllergyMedicine +7

A Multi-Ingredient Supplement Protects against Obesity and Infertility in Western Diet-Fed Mice

Mats I. Nilsson, Linda May, Liza J. Roik, +5

Nutrients

A Novel Multi-Ingredient Supplement Activates a Browning Program in White Adipose Tissue and Mitigates Weight Gain in High-Fat Diet-Fed Mice

Joshua P. Nederveen, Katherine Manta, Adam L. Bujak, +7

Nutrients

NutritionExperimental NutritionOxidative StressObesityMetabolic Syndrome +19