Tomoe Taira

DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model

Takeshi Jimbo, Mana Hatanaka, Takahiro Komatsu et al. · Oncotarget · 2019 · 48 citations · Full text

Medicine, Oncology, Pharmacology +17

Pharmacokinetic properties and oral bioavailabilities of difloxacin in pig and chicken

Takayuki Inui, Tomoe Taira, Takeji Matsushita et al. · Xenobiotica · 1998 · 32 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

Discovery of <i>trans</i>-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4<i>S</i>)-methoxy-(2<i>S</i>)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist

Fumihito Muro, Shin Iimura, Yuuichi Sugimoto et al. · Journal of Medicinal Chemistry · 2009 · 25 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid

Masaki Setoguchi, Shin Iimura, Yuuichi Sugimoto et al. · Bioorganic & Medicinal Chemistry · 2012 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models

Genzui Setsu, Megumi Goto, Kentaro Ito et al. · European Journal of Pharmacology · 2023 · 19 citations

Medicine, Medicinal Chemistry, Pharmacology +13