Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Ziming Wang, Ethan G. Aguilar, Jesus I. Luna, +30

Nature Medicine

ObesityCancer ImmunosurveillancePd-1 Checkpoint BlockadeT Cell FunctionMedicine +8

Enhanced function of pancreatic islets co-encapsulated with ECM proteins and mesenchymal stromal cells in a silk hydrogel

Nicolynn E. Davis, Liese N Beenken-Rothkopf, Annie Mirsoian, +4

Biomaterials

Regenerative MedicineHydrogelsTissue EngineeringBiopolymer GelPancreatic Islets +11

Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

Myriam N. Bouchlaka, Gail D. Sckisel, Mingyi Chen, +16

The Journal of Experimental Medicine

ImmunologyImmune RegulationPathologyImmunologic MechanismImmunotherapy +17

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice

Annie Mirsoian, Myriam N. Bouchlaka, Gail D. Sckisel, +16

The Journal of Experimental Medicine

Western Diet–Induced Dysbiosis in Farnesoid X Receptor Knockout Mice Causes Persistent Hepatic Inflammation after Antibiotic Treatment

Prasant Kumar Jena, Lili Sheng, Huixin Liu, +7

American Journal Of Pathology

InflammationWestern Diet–induced DysbiosisDysbiosisAllergyMicrobial Pathogens +9

Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies

Arta M. Monjazeb, Michael S. Kent, Steven K. Grossenbacher, +13

Clinical Cancer Research

Out-of-Sequence Signal 3 Paralyzes Primary CD4+ T-Cell-Dependent Immunity

Gail D. Sckisel, Myriam N. Bouchlaka, Arta M. Monjazeb, +14

Immunity

T-regulatory CellImmunologyAutoimmunityT Cell ImmunityOut-of-sequence Signal 3 +3

Treatment of chronic graft-versus-host disease with bortezomib

Chien-Chun Steven Pai, Mingyi Chen, Annie Mirsoian, +8

Blood

Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy

Gail D. Sckisel, Annie Mirsoian, Christine M. Minnar, +7

Journal for ImmunoTherapy of Cancer

Repeated PD-1/PD-L1 monoclonal antibody administration induces fatal xenogeneic hypersensitivity reactions in a murine model of breast cancer

Christine Mall, Gail D. Sckisel, David A. Proia, +8

OncoImmunology