W.W. Prosise

Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease–helicase

Nanhua Yao, Paul Reichert, S. Shane Taremi et al. · Structure · 1999 · 378 citations · Full text

Virus Structure, Crystal Structure, Viral Replication +12

Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

Giovanna Scapin, Venkata P. Dandey, Zhening Zhang et al. · Nature · 2018 · 261 citations · Full text

Biochemistry, Natural Sciences, Receptor (Biochemistry) +5

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

Giovanna Scapin, Xiaoyu Yang, W.W. Prosise et al. · Nature Structural & Molecular Biology · 2015 · 243 citations

Medicine, Antibody Engineering, Immunology +1

Construction, expression, and characterization of a novel fully activated recombinant single‐chain hepatitis C virus protease

S. Shane Taremi, Brian M. Beyer, M. Maher et al. · Protein Science · 1998 · 115 citations · Full text

Viral Replication, Essential Junctions, Molecular Virology +15

Discovery of the HCV NS3/4A Protease Inhibitor (1<i>R</i>,5<i>S</i>)-<i>N</i>-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(<i>S</i>)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(<i>S</i>)-carboxamide (Sch 503034) II. Key Steps in Structure-Based Optimization

Andrew Prongay, Zhuyan Guo, Nanhua Yao et al. · Journal of Medicinal Chemistry · 2007 · 106 citations · Full text

Protein Assembly, Molecular Biology, Structure-based Optimization +22