Adam Yasgar

Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries

James Inglese, Douglas S. Auld, Ajit Jadhav et al. · Proceedings of the National Academy of Sciences · 2006 · 806 citations · Full text

Drug Target, Hit Identification, Concentration-response Curves +23

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Michael E. Pacold, Kyle R. Brimacombe, Sze Ham Chan et al. · Nature Chemical Biology · 2016 · 571 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Serine Synthesis +10

THE IMPACT OF P-GLYCOPROTEIN ON THE DISPOSITION OF DRUGS TARGETED FOR INDICATIONS OF THE CENTRAL NERVOUS SYSTEM: EVALUATION USING THE MDR1A/1B KNOCKOUT MOUSE MODEL

Angela C. Doran, R. Scott Obach, Bill J. Smith et al. · Drug Metabolism and Disposition · 2004 · 440 citations

The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics

Ruili Huang, Noel Southall, Yuhong Wang et al. · Science Translational Medicine · 2011 · 409 citations

Drug Target, Bioinformatics Database, Medicinal Chemistry +20

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

Lesley A. Mathews Griner, Rajarshi Guha, Paul Shinn et al. · Proceedings of the National Academy of Sciences · 2014 · 390 citations · Full text