Low Doses of Ionizing Radiation Promote Tumor Growth and Metastasis by Enhancing Angiogenesis

Inês Sofia Vala, Leila R. Martins, Natsuko Imaizumi, +9

PLoS ONE

Radiation EffectRadiation ExposureZebrafish Fin RegenerationRadiation BiologyTumor Biology +19

Sphingolipids control dermal fibroblast heterogeneity

Laura Capolupo, Irina Khven, Alex R. Lederer, +20

Science

Human CellSystems BiologySignal TransductionCell StatesCell Signaling +12

Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas

Élodie Bal, Hyun-Sook Park, Zakia Belaid-Choucair, +33

Nature Medicine

Enhancer RnaLineage PlasticityDevelopmental BiologyMedicinePathology +7

Inhibition of the Kit Ligand/c-Kit Axis Attenuates Metastasis in a Mouse Model Mimicking Local Breast Cancer Relapse after Radiotherapy

François Kuonen, Julien Laurent, Chiara Secondini, +10

Clinical Cancer Research

Integrated multi-omics reveals cellular and molecular interactions governing the invasive niche of basal cell carcinoma

Laura Yerly, Christine Pich-Bavastro, Jérémy Di Domizio, +6

Nature Communications

Loss of Primary Cilia Drives Switching from Hedgehog to Ras/MAPK Pathway in Resistant Basal Cell Carcinoma

François Kuonen, Noelle E. Huskey, Gautam Shankar, +6

Journal of Investigative Dermatology

Signaling PathwayRas/mapk PathwayCell SignalingMedicinePathology +5

Connexins orchestrate progression of breast cancer metastasis to the brain by promoting FAK activation

Girieca Lorusso, Christof B. Wyss, François Kuonen, +14

Science Translational Medicine

TGFβ, Fibronectin and Integrin α5β1 Promote Invasion in Basal Cell Carcinoma

François Kuonen, Isabelle Surbeck, Kavita Y. Sarin, +5

Journal of Investigative Dermatology

Cancer ResearchMedicineCancer Cell BiologyCell-matrix InteractionBasal Cell Carcinoma +8

c-FOS drives reversible basal to squamous cell carcinoma transition

François Kuonen, Nancy Yanzhe Li, Daniel Haensel, +6

Cell Reports

Radiation-induced modifications of the tumor microenvironment promote metastasis

Curzio Rüegg, Yan Monnier, François Kuonen, +1

Bulletin du Cancer

Radiation TherapyRadiation-induced ModificationsBiological MicroenvironmentsMedicineRadiation Oncology +2