S. Hachiya

Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 3. Synthesis of C27-C36 Subunit<i>via</i>Completely Stereoselective<i>C</i>-Glycosylation to the F Ring

K. HORITA, Y. SAKURAI, M. NAGASAWA et al. · Synlett · 1994 · 41 citations

Engineering, Organic Chemistry, Chemistry +17

Discovery of <i>N</i> -[2-Hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (Darexaban, YM150) as a Potent and Orally Available Factor Xa Inhibitor

Fukushi Hirayama, Hiroyuki Koshio, Tsukasa Ishihara et al. · Journal of Medicinal Chemistry · 2011 · 35 citations · Full text

Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 1. Stereoselective Synthesis of the C1-C13 Fragment<i>via</i>Construction of the B and A Rings by Kinetically and thermodynamically Controlled Intramolecular Michael Reactions.

K. HORITA, S. Hachiya, M. NAGASAWA et al. · Synlett · 1994 · 34 citations

Medicinal Chemistry, Enantioselective Synthesis, Bioorganic Chemistry +14

Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 6. Synthesis of the C1-C15 Unit via Stereoselective Construction of the B and A Rings by Kinetically and Thermodynamically Controlled Michael Reactions with the Aid of Computational Search for Dominant Conformers.

Kiyoshi Horita, S. Hachiya, Tatsuya Yamazaki et al. · Chemical and Pharmaceutical Bulletin · 1997 · 21 citations · Full text

Combinatorial Chemistry, Medicinal Chemistry, Bioorganic Chemistry +15

Design, synthesis and biological activity of YM-60828 derivatives: potent and orally-Bioavailable factor Xa inhibitors based on naphthoanilide and naphthalensulfonanilide templates

Fukushi Hirayama, Hiroyuki Koshio, Tsukasa Ishihara et al. · Bioorganic & Medicinal Chemistry · 2002 · 20 citations

Biological Activity, Medicinal Chemistry, Pharmaceutical Science +12