Synthetic Studies of Halichondrin B, an Antitumor Polyether Macrolide Isolated from a Marine Sponge. 3. Synthesis of C27-C36 Subunit<i>via</i>Completely Stereoselective<i>C</i>-Glycosylation to the F Ring

Abstract

A stereoselective synthesis of the C27-C36 fragment of halichondrin B starting from L-tartaric acid using an efficient acidcatalyzed C-glycosylation to the F ring as the key step is reported.