Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells

Tanmoy Saha, Chinmayee Dash, Ruparoshni Jayabalan, +8

Nature Nanotechnology

NanotherapeuticsMitochondrial FunctionCell TraffickingImmunologyCytoskeleton +5

Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

Ilaria Elia, Jared H. Rowe, Sheila Johnson, +7

Cell Metabolism

Cancer ImmunosurveillanceT-regulatory CellImmunologyTumor ImmunityCell Death +11

Oncometabolite <scp>d</scp> -2HG alters T cell metabolism to impair CD8 ⁺ T cell function

Giulia Notarangelo, Jessica B. Spinelli, Elizabeth M. Perez, +21

Science

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Kiran Kurmi, Sadae Hitosugi, Elizabeth K. Wiese, +6

Cell Reports

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

Jefte M. Drijvers, Jacob E. Gillis, Tara Muijlwijk, +11

Cancer Immunology Research

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kiran Kurmi, Sadae Hitosugi, Jia Yu, +12

Cell Metabolism

Tumor BiologyTyrosine PhosphorylationSignal TransductionMitochondrial FunctionReceptor Tyrosine Kinase +7

BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents

Arun Kanakkanthara, Kiran Kurmi, Thomas L. Ekstrom, +14

Cancer Research

Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect

Elizabeth K. Wiese, Sadae Hitosugi, Sharon T. Loa, +7

Nature Metabolism

Reductive StressSignal TransductionBiochemistryRedox RegulatorMedicine +12

Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis

Cong-Hui Yao, Joon Seok Park, Kiran Kurmi, +7

Molecular Cell

Kidney Cancer RevealsBiochemistryMedicineNatural SciencesGlycerol-3-phosphate Shuttle +7

Circulating Mycobacterium bovis Peptides and Host Response Proteins as Biomarkers for Unambiguous Detection of Subclinical Infection

Elise A. Lamont, Harish K. Janagama, João Lima, +7

Journal of Clinical Microbiology