Targeting MYC dependence in cancer by inhibiting BET bromodomains

Jennifer A. Mertz, Andrew R. Conery, Barbara M. Bryant, +5

Proceedings of the National Academy of Sciences

Myc TranscriptChromatinTranscriptional RegulationSystems BiologyMyc Dependence +13

BET bromodomain inhibition suppresses TH17-mediated pathology

Deanna A. Mele, Andrés Salmerón, Srimoyee Ghosh, +3

The Journal of Experimental Medicine

InflammationCytokineAutoimmune DiseaseAllergyBet Inhibitor +13

Small molecule AZD4635 inhibitor of A_2AR signaling rescues immune cell function including CD103⁺ dendritic cells enhancing anti-tumor immunity

Alexandra Borodovsky, Christine M. Barbon, Yanjun Wang, +21

Journal for ImmunoTherapy of Cancer

Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer

Alexey S. Revenko, Larissa S. Carnevalli, Charles Sinclair, +25

Journal for ImmunoTherapy of Cancer

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition

Srimoyee Ghosh, Alexander M. Taylor, Melissa Chin, +33

Journal of Biological Chemistry

Signal TransductionAdaptive Immune SystemT-regulatory CellCbp/ep300 Bromodomain InhibitionImmunology +7

Systemic nano-delivery of low-dose STING agonist targeted to CD103+ dendritic cells for cancer immunotherapy

Aatman S. Doshi, Susan Cantin, Laura B. Prickett, +2

Journal of Controlled Release

NanomedicineLow-dose Sting AgonistNanotherapeuticsImmunologyTherapeutic Vaccine +8

Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity

Sophie Langdon, Adina Hughes, Molly A. Taylor, +8

OncoImmunology

ImmunologyImmune RegulationImmunoeditingImmunologic MechanismImmunotherapeutics +23

<i>STAT3</i> Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti–PD-L1

Theresa A. Proia, Maneesh Singh, Richard Woessner, +19

Clinical Cancer Research

Dipeptidyl Peptidase 2 is an essential survival factor in the regulation of cell quiescence

Deanna A. Mele, Pradeep Bista, Diana Velez Baez, +1

Cell Cycle

Neurogenin 3-Specific Dipeptidyl Peptidase-2 Deficiency Causes Impaired Glucose Tolerance, Insulin Resistance, and Visceral Obesity

Olga V. Danilova, Albert Tai, Deanna A. Mele, +8

Endocrinology

Dpp2 Enzyme ActivityMetabolic DisorderInsulin SignalingGastrointestinal Peptide HormoneOxidative Stress +18