Deanna A. Mele

Targeting MYC dependence in cancer by inhibiting BET bromodomains

Jennifer A. Mertz, Andrew R. Conery, Barbara M. Bryant et al. · Proceedings of the National Academy of Sciences · 2011 · 1.1K citations · Full text

Myc Transcript, Chromatin, Transcriptional Regulation +15

BET bromodomain inhibition suppresses TH17-mediated pathology

Deanna A. Mele, Andrés Salmerón, Srimoyee Ghosh et al. · The Journal of Experimental Medicine · 2013 · 236 citations · Full text

Inflammation, Cytokine, Autoimmune Disease +15

Small molecule AZD4635 inhibitor of A_2AR signaling rescues immune cell function including CD103⁺ dendritic cells enhancing anti-tumor immunity

Alexandra Borodovsky, Christine M. Barbon, Yanjun Wang et al. · Journal for ImmunoTherapy of Cancer · 2020 · 96 citations · Full text

Direct targeting of FOXP3 in Tregs with AZD8701, a novel antisense oligonucleotide to relieve immunosuppression in cancer

Alexey S. Revenko, Larissa S. Carnevalli, Charles Sinclair et al. · Journal for ImmunoTherapy of Cancer · 2022 · 77 citations · Full text

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition

Srimoyee Ghosh, Alexander M. Taylor, Melissa Chin et al. · Journal of Biological Chemistry · 2016 · 76 citations · Full text

Signal Transduction, Adaptive Immune System, T-regulatory Cell +9