Avoiding dynastic, assortative mating, and population stratification biases in Mendelian randomization through within-family analyses

Ben Brumpton, Eleanor Sanderson, Karl Heilbron, +26

Nature Communications

Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

Laurence J Howe, Michel G. Nivard, Tim Morris, +141

Nature Genetics

Exploiting horizontal pleiotropy to search for causal pathways within a Mendelian randomization framework

Yoonsu Cho, Philip Haycock, Eleanor Sanderson, +5

Nature Communications

Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease

Jie Zheng, Yuemiao Zhang, Humaira Rasheed, +40

International Journal of Epidemiology

Alcohol intake and cardiovascular risk factors: A Mendelian randomisation study

Yoonsu Cho, So-Youn Shin, Sungho Won, +3

Scientific Reports

Sarcopenic obesity is associated with lower indicators of psychological health and quality of life in Koreans

Yoonsu Cho, So-Youn Shin, Min‐Jeong Shin

Nutrition Research

ObesityQuality Of LifeLower IndicatorsHealth BehaviorOverweight +10

Within-family studies for Mendelian randomization: avoiding dynastic, assortative mating, and population stratification biases

Ben Brumpton, Eleanor Sanderson, Fernando Pires Hartwig, +28

Cardiometabolic RiskGenetic EpidemiologyFamily StructureSexual SelectionMendelian Randomization Studies +23

Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases

Huiling Zhao, Humaria Rasheed, Therese Haugdahl Nøst, +11

Cell Genomics

Mr EvidenceGeneticsGenetic EpidemiologyProteomic TechnologyBiostatistics +15

Quercetin up-regulates expressions of peroxisome proliferator-activated receptor γ, liver X receptor α, and ATP binding cassette transporter A1 genes and increases cholesterol efflux in human macrophage cell line

Seung-Min Lee, Ji‐Young Moon, Yoonsu Cho, +2

Nutrition Research

MedicineLiver PhysiologyQuercetin Up-regulates ExpressionsMetabolic RegulationLipoprotein Metabolism +8

Within-sibship GWAS improve estimates of direct genetic effects

Laurence J Howe, Michel G. Nivard, Tim Morris, +84

GeneticsPolygenic RiskGenetic EpidemiologyLarge-scale Family DatasetsGenome-wide Association Studies +16