Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

François Tronche, Christoph Kellendonk, Oliver Kretz et al. · Nature Genetics · 1999 · 1.8K citations

Reduced Anxiety, Psychoneuroimmunology, Stress Hormone +15

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

Paul Säftig, Michal Hetman, Wolfgang W. Schmahl et al. · The EMBO Journal · 1995 · 442 citations · Full text

Inflammation, Autoimmune Disease, Mucosal Immunology +12

Cathepsin D Deficiency Induces Lysosomal Storage with Ceroid Lipofuscin in Mouse CNS Neurons

Masato Koike, Hiroshi Nakanishi, Paul Säftig et al. · Journal of Neuroscience · 2000 · 393 citations · Full text

Cellular Neurobiology, Cellular Physiology, Social Sciences +19

Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis

Eija Siintola · Brain · 2006 · 388 citations · Full text

Congenital Ncl, Genetics, Pathology +17

Cloning and sequence analysis of cDNA for human cathepsin D.

Phyllis L. Faust, Stuart Kornfeld, John M. Chirgwin · Proceedings of the National Academy of Sciences · 1985 · 319 citations · Full text

Protein Expression, Biochemistry, Natural Sciences +13